OM-VPE grown materials for high efficiency solar cells

Organometallic sources are available for all the III-V elements and a variety of dopants; thus it is possible to use the technique to grow a wide variety of semiconductor compounds. AlGaAsSb and AlGaInAs alloys for multijunction monolithic solar cells were grown by OM-VPE. While the effort concentrated on terrestrial applications, the success of OM-VPE grown GaAs/AlGaAs concentrator solar cells (23% at 400 suns) demonstrates that OM-VPE is suitable for growing high efficiency solar cells in large quantities for space applications. In addition, OM-VPE offers the potential for substantial cost reduction of photovoltaic devices with scale up and automation and due to high process yield from reproducible, uniform epitaxial growths with excellent surface morphology

Mesenteric Vascular Dysregulation and Intestinal Inflammation Accompanies Experimental Spinal Cord Injury

Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial hypotension. Gastrointestinal (GI) tissues are critically dependent upon adequate blood flow and even brief periods of visceral hypoxia triggers GI dysmotility. The aim of this study was to test the hypothesis that T3-SCI induces visceral hypoperfusion, diminished postprandial vascular reflexes and concomitant visceral inflammation. We measured in vivo systemic arterial blood pressure and superior mesenteric artery (SMA) and duodenal blood flow in anesthetized T3-SCI rats at 3 days and 3 weeks post-injury either fasted or following enteral feeding of a liquid mixed-nutrient meal (Ensure™). In separate cohorts of fasted T3-SCI rats, markers of intestinal inflammation were assayed by qRT-PCR. Our results show that T3-SCI rats displayed significantly reduced SMA blood flow under all experimental conditions (p\u3c0.05). Specifically, the anticipated elevation of SMA blood flow in response to duodenal nutrient infusion (postprandial hyperemia) was either delayed or absent after T3-SCI. The dysregulated SMA blood flow in acutely-injured T3-SCI rats coincides with abnormal intestinal morphology and elevation of inflammatory markers, all of which resolve after 3 weeks. Specifically, Icam1, Ccl2 (MCP-1) and Ccl3 (MIP-1α) were acutely elevated following T3-SCI. Our data suggest that arterial hypotension diminishes mesenteric blood flow necessary to meet mucosal demands at rest and during digestion. The resulting GI ischemia and low-grade inflammation may be an underlying pathology leading to GI dysfunction seen following acute T3-SCI

ABC: software for interactive browsing of genomic multiple sequence alignment data

BACKGROUND: Alignment and comparison of related genome sequences is a powerful method to identify regions likely to contain functional elements. Such analyses are data intensive, requiring the inclusion of genomic multiple sequence alignments, sequence annotations, and scores describing regional attributes of columns in the alignment. Visualization and browsing of results can be difficult, and there are currently limited software options for performing this task. RESULTS: The Application for Browsing Constraints (ABC) is interactive Java software for intuitive and efficient exploration of multiple sequence alignments and data typically associated with alignments. It is used to move quickly from a summary view of the entire alignment via arbitrary levels of resolution to individual alignment columns. It allows for the simultaneous display of quantitative data, (e.g., sequence similarity or evolutionary rates) and annotation data (e.g. the locations of genes, repeats, and constrained elements). It can be used to facilitate basic comparative sequence tasks, such as export of data in plain-text formats, visualization of phylogenetic trees, and generation of alignment summary graphics. CONCLUSIONS: The ABC is a lightweight, stand-alone, and flexible graphical user interface for browsing genomic multiple sequence alignments of specific loci, up to hundreds of kilobases or a few megabases in length. It is coded in Java for cross-platform use and the program and source code are freely available under the General Public License. Documentation and a sample data set are also available

Regulation of Craniofacial Bone Healing Using Noggin

In cases of craniosynostosis, defined as the premature fusion of the cranial sutures, there is a need to inhibit bone formation in small calvarial defects to avoid the occurrence of postoperative resynostosis. Similarly, reconstruction of bone in the craniofacial skeleton following injury or tumor resection necessitates controlled bone regeneration to avoid bone overgrowth. Bone morphogenetic proteins (BMPs) are potent bone inducing growth factors that are expressed during normal bone healing. Noggin is an extracellular antagonist to BMPs. This work studied the use of Noggin to prevent postoperative resynostosis in a rabbit model of human nonsyndromic craniosynostosis via protein therapy. A mouse model of a healing suturectomy was also developed. This model was used to study the effects of Noggin ex vivo gene therapy on the inhibition of postoperative resynostosis. Finally, the ability of Noggin to inhibit bone overgrowth and improve BMP4-induced bone formation was tested. The work presented here demonstrates that a single dose of Noggin protein is capable of inhibiting resynostosis and improving craniofacial growth after surgery to correct craniosynostosis in rabbits. Noggin delivered through ex vivo gene therapy was able to inhibit bone formation in a novel mouse model. Also, the implantation of Noggin expressing cells along with BMP4 expressing cells reduced ectopic bone formation and improved bone density. These results suggest that Noggin therapy may be useful for the inhibition of postoperative resynostosis in children with craniosynostosis. Furthermore, by recreating naturally occurring expression patterns (for example, both Noggin and BMP4), we may be able to control the size, shape and quality of bone formed by biologically-driven therapies

Bayesian prediction of an epidemic curve

AbstractAn epidemic curve is a graph in which the number of new cases of an outbreak disease is plotted against time. Epidemic curves are ordinarily constructed after the disease outbreak is over. However, a good estimate of the epidemic curve early in an outbreak would be invaluable to health care officials. Currently, techniques for predicting the severity of an outbreak are very limited. As far as predicting the number of future cases, ordinarily epidemiologists simply make an educated guess as to how many people might become affected. We develop a model for estimating an epidemic curve early in an outbreak, and we show results of experiments testing its accuracy

Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4

The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair. Toll-like receptor 4 (TLR4) is a member of a highly conserved receptor family and is a critical activator of the innate immune response after tissue injury. TLR4 signaling has been shown to regulate the systemic inflammatory response induced by exposed bone components during long-bone fracture. Here we tested the hypothesis that TLR4 activation affects the healing of calvarial defects. A 1.8 mm diameter calvarial defect was created in wild-type (WT) and TLR4 knockout (TLR4-/-) mice. Bone healing was tested using radiographic, histologic and gene expression analyses. Radiographic and histomorphometric analyses revealed that calvarial healing was accelerated in TLR4-/- mice. More bone was observed in TLR4-/- mice compared to WT mice at postoperative days 7 and 14, although comparable healing was achieved in both groups by day 21. Bone remodeling was detected in both groups on postoperative day 28. In TLR4-/- mice compared to WT mice, gene expression analysis revealed that higher expression levels of IL-1β, IL-6, TNF-α,TGF-β1, TGF-β3, PDGF and RANKL and lower expression level of RANK were detected at earlier time points (≤ postoperative 4 days); while higher expression levels of IL-1β and lower expression levels of VEGF, RANK, RANKL and OPG were detected at late time points (> postoperative 4 days). This study provides evidence of accelerated bone healing in TLR4-/- mice with earlier and higher expression of inflammatory cytokines and with increased osteoclastic activity. Further work is required to determine if this is due to inflammation driven by TLR4 activation. © 2012 Wang et al

The Arizona CDFS Environment Survey (ACES): A Magellan/IMACS Spectroscopic Survey of the Chandra Deep Field South

We present the Arizona CDFS Environment Survey (ACES), a recently-completed spectroscopic redshift survey of the Chandra Deep Field South (CDFS) conducted using IMACS on the Magellan-Baade telescope. In total, the survey targeted 7277 unique sources down to a limiting magnitude of R = 24.1, yielding 5080 secure redshifts across the ~30' x 30' extended CDFS region. The ACES dataset delivers a significant increase to both the spatial coverage and the sampling density of the spectroscopic observations in the field. Combined with previously-published, spectroscopic redshifts, ACES now creates a highly-complete survey of the galaxy population at R < 23, enabling the local galaxy density (or environment) on relatively small scales (~1 Mpc) to be measured at z < 1 in one of the most heavily-studied and data-rich fields in the sky. Here, we describe the motivation, design, and implementation of the survey and present a preliminary redshift and environment catalog. In addition, we utilize the ACES spectroscopic redshift catalog to assess the quality of photometric redshifts from both the COMBO-17 and MUSYC imaging surveys of the CDFS.Comment: resubmitted to MNRAS; 12 pages, 12 figures, and 3 tables; updated redshift catalog available at http://mur.ps.uci.edu/~cooper/ACES

Design & manufacture of a high-performance bicycle crank by additive manufacturing

A new practical workflow for the laser Powder Bed Fusion (PBF) process, incorporating topological design, mechanical simulation, manufacture, and validation by computed tomography is presented, uniquely applied to a consumer product (crank for a high-performance racing bicycle), an approach that is tangible and adoptable by industry. The lightweight crank design was realised using topology optimisation software, developing an optimal design iteratively from a simple primitive within a design space and with the addition of load boundary conditions (obtained from prior biomechanical crank force–angle models) and constraints. Parametric design modification was necessary to meet the Design for Additive Manufacturing (DfAM)considerations for PBF to reduce build time, material usage, and post-processing labour. Static testing proved performance close to current market leaders with the PBF manufactured crank found to be stiffer than the benchmark design (static load deflection of 7.0±0.5 mm c.f. 7.67mm for a Shimano crank at a competitive mass (155g vs. 175g). Dynamic mechanical performance proved inadequate, with failure at 2495±125cycles; the failure mechanism was consistent in both its form and location. This research is valuable and novel as it demonstrates a complete work flow from design, manufacture, post-treatment, and validation of a highly loaded PBF manufactured consumer component, offering practitioners a validated approach to the application of PBF for components with application outside of the accepted sectors (aerospace, biomedical, autosports, space, and power generation)